Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes

Diabetes constitutes a world-wide pandemic that requires searching for new treatments to halt its progression. Cellular senescence of pancreatic beta cells has been described as major contributor development and worsening diabetes. The concept reversibility cellular is critical the timing take actions against this “dormant” senescent state. reversal can be considered rejuvenation specific cell if it returns original “healthy state” doesn’t behave aberrantly seen in some cancer cells. In rodents, treatment with senolytics senomorphics blunted or prevented disease progression, however their use carry drawbacks. Modulators area research seeks reverse senescence. More each these modalities should lead stop diabetes